The draw for this season's Carabao Cup quarter-finals was conducted on Wednesday night.
Holders Liverpool will be away to Southampton, while Arsenal host Crystal Palace.
The tie of the round will undoubtedly be Manchester United's trip to Tottenham Hotspur.
Newcastle will welcome Brentford in the last game of the next round.
CARABAO CUP QUARTER-FINAL FIXTURES:
Tottenham vs Manchester United
Arsenal vs Crystal Palace
Newcastle vs Brentford
Southampton vs Liverpool
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