Fabio Carvalho's deflected strike put the Reds in the lead after 10 minutes.
Curtis Jones made it 2-0 later in the first half after Mo Salah's excellent setup for his Liverpool teammate.
Just after the hour mark, Konstantinos Tsimikas tapped in from close range to make it 3-0, as the Reds cruised to victory over their bitter rivals.
Match result: Man Utd 0-3 Liverpool
Man Utd team: Onana, Wan-Bissaka, Evans, Lindelof, Amass, Casemiro, Collyer, Amad, Mount, Rashford, Sancho
Liverpool team: Kelleher, Bradley, Konate, Quansah, Tsimikas, Jones, Gravenberch, Salah, Elliott, Carvalho, Jota
Liverpool's pre-season fixtures and results
19 July: Liverpool 0-1 Preston
27 July: Liverpool 1-0 Real Betis
1 August: Liverpool 2-1 Arsenal
3 August: Liverpool 3-0 Manchester United
11 August: Liverpool vs Sevilla, Anfield (15:00)
Manchester United's Pre-Season Fixtures and Results
July 15: Rosenborg 1-0 Man Utd
July 20: Rangers 0-2 Man Utd
July 28: Arsenal 2-1 Man Utd
August 1: Man Utd 3-2 Real Betis
August 4: Man Utd 0-3 Liverpool
August 10 - Community Shield: Man City vs Man Utd - Wembley, kick-off 3pm
Eight of Manchester United's 18 attempts at goal were on target, but none managed to beat either Caoimhin Kelleher or Vítezslav Jaros.
Manchester United's pre-season tour of the US ended with a 3-0 defeat to Liverpool.
The club's two bald Dutch managers shared an embrace at the final whistle, but one was undoubtedly much happier with the evening's outcome.
While United played well for large parts of the match, they were wasteful in front of goal and made costly defensive errors.
In contrast, Liverpool was clinical and used the final third of the match to give playing time to their impressive youngsters.
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