William Troost-Ekong and Zaidu Sanusi are doubtful for Nigeria's final Group A fixture against Guinea-Bissau.
The encounter is slated for the Felix Houphouet Boigny Stadium, Abidjan on Monday (today).
The duo missed the team's final training session on Sunday night.
Troost-Ekong scored the decisive goal in Super Eagles' 1-0 victory against hosts, Cote d'Ivoire last Saturday.
That PAOK Salonica centre-back is expected to be replaced in the starting line-up by Calvin Bassey.
Bruno Onyemaechi could take the place of Sanusi at left-back.
The Super Eagles need a point from the game to confirm their place in the Round of 16.
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